Protea caffra is used as a diarrhoeal remedy in South African herbal medicine, however, its\npharmacological properties remain largely unknown. In the present study, extracts from different\nProtea caffra organs were screened against drug-sensitive and -resistant diarrhoeagenic pathogens\nusing the microdilution assay (minimum inhibitory concentration, MIC). Twig extracts (70% methanol,\nMeOH) of the plant were purified and the resultant fractions screened for antibacterial properties\n(MIC). The chemical profiles of the fractions were determined by Gas Chromatography-Mass\nSpectrometry (GC-MS), while ultra-high-performance liquid chromatography-tandem mass\nspectrometry (UHPLC-MS/MS) was used to quantify the phenolic acids in the plant. The mutagenic\nproperties of bioactive extracts were assessed using the Ames test.......................
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